Changes of Regulatory T cells after Allergen-specific Subcutaneous Immunotherapy, Rush Protocol, in Children
نویسندگان
چکیده
منابع مشابه
Immunotherapy – 2071. Strail levels decreased after allergen-subcutaneous specific immunotherapy
Background TRAIL is present in cells involved in asthma including eosinophils, mast cells, fibroblasts, and airway epithelial cells. It is expressed in airway remodeling and may be linked with the pathways of transforming growth factorbeta1, which is thought to cause damage to the epithelium. The repair process of the epithelium is hindered as a result of increased apoptosis induced by TGF-beta...
متن کاملAllergen-specific immunotherapy in children
HISTORICAL TIPS The science of “Immunology” originated in the 19th century and grass pollens were identified for the first time as the likely trigger of seasonal hay fever in the 1870s. Skin allergy testing became an accepted assessment technique around 1910. Immunoglobulin E (IgE) was identified in the 1960s. The first scholarly report of immunotherapy for allergy appeared by Noon and Freeman ...
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Background: Synbiotics have been used in the prevention and treatment of various immunological diseases. We aimed to investigate the synergistic clinical and immunologic effects of synbiotics and subcutaneous allergen immunotherapy (SCIT) combination in patients with allergic rhinitis. Materials and Methods: Nineteen individuals with all...
متن کاملIL-10 and regulatory T cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma.
Human studies demonstrated that allergen-specific immunotherapy (IT) represents an effective treatment for allergic diseases. IT involves repeated administration of the sensitizing allergen, indicating a crucial contribution of T cells to its medicinal benefit. However, the underlying mechanisms of IT, especially in a chronic disease, are far from being definitive. In the current study, we soug...
متن کاملMechanism of Regulatory T Cells During Allergen-Specific Immunotherapy: from the Past to Future
Since the first trial reported by Noon about a century ago [1], allergen-specific immunotherapy (SIT) by repeated subcutaneous administration of increased doses of allergen extracts has a long-lasting effect on immunologic tolerance to common environmental allergens [2-4]. Allergen-specific subcutaneous immunotherapy (SCIT) has been effectively used for the treatment choice for allergic rhiniti...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.12.870